Anti-histone Antibody-Cytokine Fusion Protein, IgG (NHS76)-IL12
CAT#: ACFP-SH113
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-histone IgG to IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the histone as well as the biological activity of IL12. NHS-IL12 is a fusion protein comprising two IL12 heterodimers combined to the H-chain of an NHS76 monoclonal antibody. Murine in-vivo models have shown NHS-IL12 to be safe and efficacious with a subcutaneous route of administration showing the best results. The addition of the human IgG1 moiety resulted in a longer plasma half-life of NHS-IL12 than recombinant IL12, and a selective targeting to murine tumors in vivo. This immunocytokine was designed for treating necrotic tumor.
Tested Data
ELISA
Figure 1 Anti-histone Antibody-Cytokine Fusion Protein, IgG-IL12 (ACFP-SH113) in ELISA
ELISA analysis of ACFP-SH113 was performed by coating with Histone H2A human.
The secondary antibody: HRP Goat Anti-human IgG
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Specifications
- Target
- Histone
- Molecule Class
- IgG1-IL12
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- NHS76
- Related Disease
- Necrotic tumor
- Cytokine 1
- IL12
- Cytokines 1 Description
- Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
- Cytokine 1 Species
- Mouse
- Cytokines 2 Description
- histone
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Histones; histone HI; histone H3; histone H2B; histone H4; histone H2A
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